Jaime Marshall, a Wisconsin resident, has experienced a significant change in her life following a liver transplant that cured her of maple syrup urine disease (MSUD), a rare inherited metabolic disorder. This condition prevented her body from breaking down certain amino acids found in protein-rich foods, leading to severe health issues.
Dr. Jessica Musto, a transplant hepatologist at UW Health and assistant professor at the University of Wisconsin School of Medicine and Public Health, explained the dangers of MSUD: “Without the proper diagnosis and treatment, the toxins can damage organs very quickly and cause brain damage.” Patients with this condition require lifelong monitoring to ensure they receive adequate nutrition.
Marshall's struggle began as an infant when she spent nearly two weeks in the hospital until a nurse identified the sweet-smelling urine characteristic of MSUD. Her life involved regular medical check-ups and adherence to a strict low-protein diet. Despite these challenges, her sister Vikki Ness admired Marshall's resilience: “Jaime didn’t have it easy, but she took it in stride.”
In August 2023, Marshall's health declined due to symptoms associated with encephalopathy and fatty liver disease. The team at University Hospital attempted stabilization through medication but ultimately determined that a liver transplant was necessary based on her Model for End-Stage Liver Disease (MELD) score.
Encouraged by their mother Christine Ness before her passing in January 2024, Marshall considered transplantation options. She discussed this with Ness who expressed willingness to become a living donor despite initial uncertainties about blood type compatibility.
The evaluation process confirmed Ness as compatible after extensive testing conducted by UW Health Transplant Center under Melissa Schafer’s coordination: “It is crucial that living donors know what they are getting themselves into.”
On May 28th at University Hospital Madison surgery commenced led by Drs David Al-Adra & David Aufhauser removing 70% of Ness' liver which was transplanted into Marshall curing her MSUD instantly post-operation according to Schafer "Vikki was on mission help sister entire team honored give gift both women."
Both sisters have since been recovering successfully; Marshall adapting heart-healthy diet enjoying physical activities while expressing gratitude towards those involved including medical staff family members particularly acknowledging unwavering support received throughout journey alongside loved ones like sister children late mother stating readiness embrace new chapter life ahead together cherished individuals around them
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